Efficacy of pyrvinium pamoate against Cryptosporidium parvum infection in 1 vitro and in a neonatal mouse model 2 3 Running title : Inhibition of
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چکیده
* Corresponding author: David J. Sullivan. Mailing address: Department of Molecular 17 Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, 18 615 N. Wolfe St., Baltimore, Maryland 21205, USA. Phone: (410) 502-2522, FAX: (410) 95519 0105. E-mail: [email protected] 20 21 22 23 A CE PT ED Copyright © 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved. Antimicrob. Agents Chemother. doi:10.1128/AAC.00207-08 AAC Accepts, published online ahead of print on 30 June 2008
منابع مشابه
Efficacy of pyrvinium pamoate against Cryptosporidium parvum infection in 1 vitro and in a neonatal mouse model 2 3 Running title : Inhibition of Cryptosporidium by pyrvinium 4 5 Autumn
* Corresponding author: David J. Sullivan. Mailing address: Department of Molecular 17 Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, 18 615 N. Wolfe St., Baltimore, Maryland 21205, USA. Phone: (410) 502-2522, FAX: (410) 95519 0105. E-mail: [email protected] 20 21 22 23 A CE PT ED Copyright © 2008, American Society for Microbiology and/or the Listed A...
متن کاملEfficacy of pyrvinium pamoate against Cryptosporidium parvum infection in vitro and in a neonatal mouse model.
No effective approved drug therapy exists for Cryptosporidium infection of immunocompromised patients. Here we investigated the nonabsorbed anthelmintic drug pyrvinium pamoate for inhibition of the growth of the intestinal protozoan parasite Cryptosporidium parvum. The concentration of pyrvinium that effected 50% growth inhibition in human enterocytic HCT-8 cells by a quantitative alkaline phos...
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Purpose: The purpose of this study is to model Cryptosporidiosis in laboratory animals. The parasites were inoculated into animalsand thenmultiplied. The process of proliferation was compared to controlCryptosporidiosis in humans. Materials and Methods: Twenty-five laboratory mice (4-7 days of age) and twenty-five laboratory rats (5 days of age) were assigned to the category I while the cat...
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Cryptosporidium parvum is a zoonotic protozoan parasite that may cause severe neonatal diarrhoea or even mortality in newborn ruminants: its oocysts are extremely resistant to normal environmental conditions and to most common disinfectants. KENO™COX, a patent pending amine-based formula, was tested for its ability to inactivate C. parvum oocysts. The Daugschies assay (2002), a standardized ass...
متن کاملNF-kappaB-mediated expression of iNOS promotes epithelial defense against infection by Cryptosporidium parvum in neonatal piglets.
Cryptosporidium sp. parasitizes intestinal epithelium, resulting in enterocyte loss, villous atrophy, and malabsorptive diarrhea. We have shown that mucosal expression of inducible nitric oxide (NO) synthase (iNOS) is increased in infected piglets and that inhibition of iNOS in vitro has no short-term effect on barrier function. NO exerts inhibitory effects on a variety of pathogens; neverthele...
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